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decreased expression of miR-122 and increased expression of TRIM29 was significantly associated with poor prognosis in patients with NPC.
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Ectopic expression of TRIM29 potentially contributes to metastasis and poor prognosis in patients with osteosarcoma.
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Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus.
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the current study demonstrated that TRIM29 upregulates cyclin and Bcl family proteins level to facilitate malignant cell growth and inhibit drug-induced apoptosis in bladder cancer, possibly through PKC-NF-kappaB signaling pathways.
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High TRIM29 expression is associated with metastasis of nasopharyngeal carcinoma.
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Data show that TRIM29 promotes tumor progression by activating Wnt/beta-Catenin signaling.
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This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM-dependent breast cancer suppression.
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Upregulation of TRIM29 is associated with thyroid cancer.
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miR-761 acts as an oncogene in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29.
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Silencing of TRIM29 significantly inhibited the migration and invasion ability of CRC cells.
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Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target.
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define a novel function for ATDC in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC
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Results suggest that TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185.
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TRIM29 functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DNA damage response.
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These findings suggest that TRIM29 regulates the p63-mediated pathway and the behavior of cervical cancer cells.
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Down-regulation of ATDC inhibits the growth and proliferation of esophageal carcinoma cells.
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TRIM29 may be useful marker for distinguishing prostate cancers from benign tissues
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TWIST1 inhibited TRIM29 promoter activity.
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TRIM29 promotes tumor progression and may be a novel prognostic marker for pancreatic ductal adenocarcinoma.
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Down-regulation of TRIM29 inhibited tumor cell proliferation in vitro.
