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Human DPP4 Protein expressed in Insect Cells - ABIN5570005
Shiobara, Chibana, Watanabe, Arai, Horigane, Nakamura, Hayashi, Shimizu, Takemasa, Ishii: Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of untreated asthma and it increases cell proliferation along with fibronectin production in airway constitutive cells. in Respiratory research 2016
API was demonstrated to inhibit the migration/invasion of NSCLC cells harboring different EGFR statuses via suppressing the Snail/Slug-mediated EMT..CD26 may be a useful biomarker for predicting NSCLC progression. API effectively suppressed lung cancer progression by targeting the CD26-Akt-Snail/Slug signaling pathway
hepatocyte DPP4 promotes visceral adipose tissue inflammation and insulin (show INS Proteins) resistance in obesity, and targeting this pathway may have metabolic benefits that are distinct from those observed with oral DPP4 inhibitors
this study shows that CD26 expression is down-regulated on CD8 (show CD8A Proteins)(+) T cells in patients with Hashimoto's thyroiditis
Several isoforms of DPP-IV and FAP are present in glioblastoma tissue. The absence of alkaline isoforms of both enzymes in glioma cell lines however suggests that isoforms from other, most likely stromal, cell types contribute to the overall pattern seen in glioblastoma tissues.
Data suggest that dipeptidyl peptidase 4 (DPPIV) gene polymorphism influences disease susceptibility and acute pancreatitis (AP) severity.
DPP-4 activity and GLP (show RCBTB1 Proteins)-1total levels were higher in patients with microvascular complications associated with T2DM. Contrary to expectations, no negative correlation was seen between GLP-1 (show GCG Proteins) and DDP (show TIMM8A Proteins)-4 levels. This result suggests the possible inefficacy of DDP (show TIMM8A Proteins)-4 activity as a marker to predict in vivo degradation of endogenous GLP-1 (show GCG Proteins).
The study showed that DPP-4 inhibitor use does not modify the risk of bone fracture compared with placebo or other anti-diabetic medications in patients with type 2 diabetes.
A close connection between SerpinB3 (show SERPINB3 Proteins) and DPPPIV has been identified, but further studies are required to better understand the mechanism by which these proteins communicate and exert metabolic effects in hepatocellular carcinoma.
There is a U-shaped association of serum DPP-IV with mortality in chronic heart failure patients.
Levels of DPPIV enzyme activity in sera of patients with psoriatic pruritus were significantly increased compared to those of healthy controls.
Results describe a proline-rich cytokine from neurosecretory granules that represents a new natural substrate for Dipeptidyl Peptidase IV (DPPIV).
Data demonstrate that dipeptidyl peptidase II (show DPP7 Proteins) can form a complex with adenosine deaminase (show ADA Proteins), but with one order of magnitude higher dissociation constant than that of DPPIV.
This study shows that porcine DPP-IV is generally inhibited with greater potency by protein-derived peptides than is the human enzyme
DPP-IV from porcine kidney cortex was characterized.
Neutral endopeptidase 24.11 (show MME Proteins) and DPP-IV is superior to DPP-IV inhibition alone in preserving intact GLP-1 (show GCG Proteins), which implies possibility that the combination has therapeutic potential.
Results describe the distribution of dipeptidyl peptidase IV-like activity enzymes in porcine tissue sections by RT-PCR.
DPP-4 inhibition with linagliptin slowed the progression of premature aging in klotho (show KL Proteins)-/- mice. Provide a novel insight into the potential role of DPP-4 in the mechanism of premature aging.
Chronic stress accelerates DPP4-mediated GLP-1 degradation and alters plasma adiponectin, accelerating vascular senescence and impairing ischemia-induced neovascularization.
p53 (show TP53 Proteins) limits ferroptosis of colorectal cancer cells by blocking DPP4 activity.
DPP4 can regulate chronic stress-induced hematopoietic stemc cell activation and inflammatory cell production via an Adrbeta3/CXCL12 (show CXCL12 Proteins)-dependent mechanism that is mediated by the GLP-1/GLP-1R (show GLP1R Proteins) axis.
DPPIV-knockout mice showed attenuation of scratching in psoriatic pruritus disease model.
Actions of several substrate chemokines might be potentiated by downregulation of DPP-4, synergistically with upregulation of chemokines and their receptors in adipose tissues of obese mice.
Inhibition of DPP-4 activity by linagliptin reverses Western diet-induced diastolic dysfunction, possibly by targeting TRAF3IP2 (show TRAF3IP2 Proteins) expression and its downstream inflammatory signaling.
DPP4 is pro-fibrotic in Carbon tetrachloride-induced liver fibrosis.
systemic DPP4 inhibition restores the impaired mononuclear cell homing in Eng (show ENG Proteins)+/- animals post-myocardial infarction, and enhances cardiac repair, which might be explained by restoring the balance between the inflammatory and regenerative macrophages present in the heart
The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.
, DPP IV
, T-cell activation antigen CD26
, adenosine deaminase complexing protein 2
, dipeptidyl peptidase 4
, dipeptidyl peptidase IV
, dipeptidylpeptidase 4
, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
, activation molecule 3
, adenosine deaminase complexing protein
, dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
, dipeptidyl-peptidase iv
, dipeptidyl-peptidase 4
, dipeptidyl-peptidase IV
, dipeptidylpeptidase IV
, thymocyte-activating molecule
, GP110 glycoprotein
, bile canaliculus domain-specific membrane glycoprotein