Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1) (C-Term) Peptide
NR5A1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all NR5A1 products
- NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))
- Protein Region
- C-Term
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- VADQMTLLQN CWSELLVLDH IYRQVQYGKE DSILLVTGQE VELSTVAVQA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Nr5a1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))
- Synonyms
- AD4BP Peptide, ELP Peptide, FTZ1 Peptide, FTZF1 Peptide, POF7 Peptide, SF-1 Peptide, SF1 Peptide, SPGF8 Peptide, SRXY3 Peptide, Ad4BP Peptide, ELP-3 Peptide, Ftz-F1 Peptide, Ftzf1 Peptide, Ad4BP/SF-1 Peptide, Ad4bp Peptide, Sf-1 Peptide, NR5A1 Peptide, sf-1 Peptide, elp Peptide, sf1 Peptide, ftz1 Peptide, ad4bp Peptide, ftzf1 Peptide, SF-1/Ad4BP Peptide, SI:zC167P9.2 Peptide, ff1d Peptide, nr5a2l Peptide, nuclear receptor subfamily 5 group A member 1 Peptide, nuclear receptor subfamily 5, group A, member 1 Peptide, nuclear receptor subfamily 5 group A member 1 L homeolog Peptide, nuclear receptor subfamily 6 group A member 1 Peptide, nuclear receptor subfamily 5, group A, member 1b Peptide, NR5A1 Peptide, Nr5a1 Peptide, nr5a1.L Peptide, nr5a1 Peptide, NR6A1 Peptide, nr5a1b Peptide
- Background
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Nr5a1 is a transcriptional activator. It seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. It binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Nr5a1 also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Nr5a1 binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Nr5a1 is activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Alias Symbols: Ad4BP, ELP, ELP-3, Ftz-F1, Ftzf1, SF-1, SF1
Protein Size: 462 - Molecular Weight
- 52 kDa
- Gene ID
- 26423
- NCBI Accession
- NM_139051, NP_620639
- UniProt
- P33242
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