Legumain (LGMN) (Middle Region) Peptide
LGMN
Reactivity: Human
Host: Synthetic
BP, WB
-
- Target See all LGMN products
- LGMN (Legumain (LGMN))
- Protein Region
- Middle Region
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ESSYACYYDE KRSTYLGDWY SVNWMEDSDV EDLTKETLHK QYHLVKSHTN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-LGMN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- LGMN (Legumain (LGMN))
- Synonyms
- AEP Peptide, LGMN1 Peptide, PRSC1 Peptide, AI746452 Peptide, AU022324 Peptide, Prsc1 Peptide, MGC64351 Peptide, cb173 Peptide, cb460 Peptide, sb:cb173 Peptide, zgc:76953 Peptide, wu:fa98g05 Peptide, wu:fj92g08 Peptide, lgmn Peptide, MGC88980 Peptide, DELTA VACUOLAR PROCESSING ENZYME Peptide, DELTAVPE Peptide, delta vacuolar processing enzyme Peptide, legumain Peptide, legumain L homeolog Peptide, delta vacuolar processing enzyme Peptide, Legumain Peptide, LGMN Peptide, Lgmn Peptide, lgmn.L Peptide, lgmn Peptide, DELTA-VPE Peptide, MBOO_RS07785 Peptide, Odosp_3582 Peptide, LOC569153 Peptide
- Background
-
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
Alias Symbols: AEP, LGMN1, PRSC1
Protein Size: 433 - Molecular Weight
- 48 kDa
- Gene ID
- 5641
- NCBI Accession
- NM_005606, NP_005597
- UniProt
- Q99538
-
You are here:
