DNA Repair Protein Complementing XP-G Cells (ERCC5) (N-Term) Peptide
ERCC5
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ERCC5 products
- ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- HSGHIRRQYE DEGGFLKEVE SRRVVSEDTS HYILIKGIQA KTVAEVDSES
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ERCC5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))
- Synonyms
- COFS3 Peptide, ERCM2 Peptide, UVDR Peptide, XPG Peptide, XPGC Peptide, cofs3 Peptide, ercm2 Peptide, uvdr Peptide, xpg Peptide, xpgc Peptide, Xpg Peptide, ERCC excision repair 5, endonuclease Peptide, excision repair cross-complementation group 5 L homeolog Peptide, excision repair cross-complementing rodent repair deficiency, complementation group 5 Peptide, ERCC5 Peptide, ercc5.L Peptide, Ercc5 Peptide
- Background
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This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
Protein Size: 1180 - Molecular Weight
- 130 kDa
- Gene ID
- 2073
- UniProt
- P28715
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