SMAD, Mothers Against DPP Homolog 6 (SMAD6) (C-Term) Peptide
SMAD6
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all SMAD6 products
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
- Protein Region
- C-Term
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PDGVWAYNRG EHPIFVNSPT LDAPGGRALV VRKVPPGYSI KVFDFERSGL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Smad6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
- Synonyms
- madh6 Peptide, madh7 Peptide, Xsmad6 Peptide, hst17432 Peptide, AOVD2 Peptide, HsT17432 Peptide, MADH6 Peptide, MADH7 Peptide, Madh6 Peptide, b2b390Clo Peptide, Smad6-like Peptide, smad6 Peptide, wu:fb22g05 Peptide, SMAD family member 6 Peptide, SMAD family member 6a Peptide, smad6 Peptide, SMAD6 Peptide, Smad6 Peptide, smad6a Peptide
- Background
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Smad6 binds to regulatory elements in target promoter regions. It may block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. It acts as a mediator of TGF-beta and BMP antiflammatory activity. It suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.
Protein Size: 459 - Molecular Weight
- 54 kDa
- Gene ID
- 17130
- UniProt
- O35182
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