Caspase Recruitment Domain Family, Member 8 (CARD8) (N-Term) Peptide
CARD8
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CARD8 products
- CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))
- Protein Region
- N-Term
- Origin
- Human
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LGGTFPGDIC SEENQIVSSY ASKVCFEIEE DYKNRQFLGP EGNVDVELID
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CARD8 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))
- Synonyms
- CARD8 Peptide, CARDINAL Peptide, DACAR Peptide, DAKAR Peptide, NDPP Peptide, NDPP1 Peptide, TUCAN Peptide, caspase recruitment domain family, member 8 Peptide, caspase recruitment domain-containing protein 8 Peptide, caspase recruitment domain family member 8 Peptide, CARD8 Peptide, LOC718594 Peptide
- Background
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The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.
Protein Size: 286 - Gene ID
- 22900
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