Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3) (C-Term) Peptide
ROBO3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ROBO3 products
- ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- HPSRSPSAQE PRGSCCPSNP DPDDRYYNEA GISLYLAQTA RGTAAPGEGP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ROBO3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
- Synonyms
- HGPPS Peptide, HGPS Peptide, RBIG1 Peptide, RIG1 Peptide, CG14345 Peptide, CT17158 Peptide, Robo-3 Peptide, Robo3 Peptide, dRobo-3 Peptide, DmelCG5423 Peptide, CG5423 Peptide, ROBO3 Peptide, robo3 Peptide, DKFZp468G0223 Peptide, Rbig1 Peptide, Rig-1 Peptide, Rig1 Peptide, Robo3a Peptide, Robo3b Peptide, cb503 Peptide, roundabout guidance receptor 3 Peptide, roundabout 3 Peptide, robo3 Peptide, roundabout guidance receptor 3 L homeolog Peptide, roundabout, axon guidance receptor, homolog 3 (Drosophila) Peptide, ROBO3 Peptide, robo3 Peptide, Robo3 Peptide, LOC658818 Peptide, robo3.L Peptide
- Background
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This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
Alias Symbols: ROBO3,
Protein Size: 1386 - Gene ID
- 64221
- NCBI Accession
- NP_071765
- UniProt
- Q96MS0
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