Adenomatous Polyposis Coli (APC) (Middle Region) Peptide
APC
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all APC products
- APC (Adenomatous Polyposis Coli (APC))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SETFDNIDNL SPKASHRSKQ RHKQSLYGDY VFDTNRHDDN RSDNFNTGNM
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-APC Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- APC (Adenomatous Polyposis Coli (APC))
- Synonyms
- dp2 Peptide, dp3 Peptide, fap Peptide, fpc Peptide, xapc Peptide, dp2.5 Peptide, AI047805 Peptide, AU020952 Peptide, AW124434 Peptide, CC1 Peptide, Min Peptide, mAPC Peptide, BTPS2 Peptide, DP2 Peptide, DP2.5 Peptide, DP3 Peptide, GS Peptide, PPP1R46 Peptide, RATAPC Peptide, APC1 Peptide, APC, WNT signaling pathway regulator Peptide, adenomatous polyposis coli Peptide, adenomatous polyposis coli protein, putative Peptide, adenomatosis polyposis coli Peptide, adenomatous polyposis coli L homeolog Peptide, APC Peptide, apc Peptide, Smp_139190 Peptide, Apc Peptide, apc.L Peptide
- Background
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This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Alias Symbols: GS, DP2, DP3, BTPS2, DP2.5, PPP1R46
Protein Size: 1304 - Gene ID
- 324
- NCBI Accession
- NM_000038, NP_000029
- UniProt
- E9PFT7
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