Thymine-DNA Glycosylase (TDG) (Middle Region) Peptide
TDG
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TDG products
- TDG (Thymine-DNA Glycosylase (TDG))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PVESKKSGKS AKSKEKQEKI TDTFKVKRKV DRFNGVSEAE LLTKTLPDIL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- TDG Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TDG (Thymine-DNA Glycosylase (TDG))
- Synonyms
- 5-MCDG Peptide, wu:fb44b11 Peptide, zgc:110622 Peptide, MGC82456 Peptide, MGC89441 Peptide, E130317C12Rik Peptide, JZA-3 Peptide, Jza1 Peptide, hTDG Peptide, thymine DNA glycosylase Peptide, thymine DNA glycosylase, tandem duplicate 1 Peptide, putative g/t mismatch-specific thymine DNA glycosylase Peptide, G/T mismatch-specific thymine DNA glycosylase Peptide, thymine DNA glycosylase S homeolog Peptide, thymine-DNA glycosylase Peptide, TDG Peptide, tdg.1 Peptide, Smp_149220 Peptide, Tsp_05734 Peptide, tdg.S Peptide, tdg Peptide, Tdg Peptide
- Background
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The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
Alias Symbols: hTDG
Protein Size: 410 - Gene ID
- 6996
- NCBI Accession
- NM_003211, NP_003202
- UniProt
- Q13569
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