Mitogen-Activated Protein Kinase 10 (MAPK10) (Middle Region) Peptide
MAPK10
Reactivity: Human
Host: Synthetic
WB
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- Target See all MAPK10 products
- MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Western Blotting (WB)
- Sequence
- VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))
- Synonyms
- MAPK10 Peptide, zgc:123234 Peptide, DKFZp459H0638 Peptide, Jnk3 Peptide, SAPKC Peptide, SAPb Peptide, Serk2 Peptide, JNK3 Peptide, JNK3A Peptide, PRKM10 Peptide, SAPK1b Peptide, p493F12 Peptide, p54bSAPK Peptide, C230008H04Rik Peptide, JNK3B1 Peptide, JNK3B2 Peptide, SAPK(beta) Peptide, ATMPK10 Peptide, MAP kinase 10 Peptide, mitogen-activated protein kinase 8 S homeolog Peptide, mitogen-activated protein kinase 10 Peptide, mitogen activated protein kinase 10 Peptide, MAP kinase 10 Peptide, mapk8.S Peptide, MAPK10 Peptide, mapk10 Peptide, Mapk10 Peptide, MPK10 Peptide
- Background
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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK
Protein Size: 167 - Gene ID
- 5602
- NCBI Accession
- NM_002753, NP_002744
- UniProt
- P53779
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