MutL Homolog 1 (MLH1) (Middle Region) Peptide
MLH1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MLH1 products
- MLH1 (MutL Homolog 1 (MLH1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- AAKNQSLEGD TTKGTSEMSE KRGPTSSNPR KRHREDSDVE MVEDDSRKEM
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- MLH1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MLH1 (MutL Homolog 1 (MLH1))
- Synonyms
- CG11482 Peptide, Dmel\\CG11482 Peptide, dmlh-1 Peptide, dmlh1 Peptide, zgc:66301 Peptide, MLH1 Peptide, LOC100232198 Peptide, 1110035C23Rik Peptide, AI317206 Peptide, AI325952 Peptide, AI561766 Peptide, COCA2 Peptide, FCC2 Peptide, HNPCC Peptide, HNPCC2 Peptide, hMLH1 Peptide, mutL homolog 1 Peptide, CG11482 gene product from transcript CG11482-RB Peptide, mutL homolog 1 S homeolog Peptide, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) Peptide, DNA mismatch repair protein Mlh1 Peptide, MLH1 Peptide, Mlh1 Peptide, mlh1.S Peptide, mlh1 Peptide, LOC588545 Peptide
- Background
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This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
Alias Symbols: FCC2, COCA2, HNPCC, hMLH1, HNPCC2
Protein Size: 515 - Gene ID
- 4292
- NCBI Accession
- NM_000249, NP_000240
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