Cyclin-Dependent Kinase 6 (CDK6) (Middle Region) Peptide
CDK6
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CDK6 products
- CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DVDQLGKILD VIGLPGEEDW PRDVALPRQA FHSKSAQPIE KFVTDIDELG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- CDK6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
- Synonyms
- CDK6 Peptide, PLSTIRE Peptide, 5830411I20 Peptide, AI504062 Peptide, Crk2 Peptide, cyclin dependent kinase 6 Peptide, cyclin-dependent kinase 6 Peptide, CDK6 Peptide, Cdk6 Peptide
- Background
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The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alias Symbols: MCPH12, PLSTIRE
Protein Size: 326 - Gene ID
- 1021
- NCBI Accession
- NM_001145306, NP_001138778
- UniProt
- Q00534
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