Minichromosome Maintenance Complex Component 6 (MCM6) (C-Term) Peptide
MCM6
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MCM6 products
- MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KRIIEKVIHR LTHYDHVLIE LTQAGLKGST EGSESYEEDP YLVVNPNYLL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- MCM6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
- Synonyms
- CG4039 Peptide, DmMCM6 Peptide, DmeMCM6 Peptide, Dmel\\CG4039 Peptide, MCM6 Peptide, McM6 Peptide, fs(1)K1214 Peptide, mcm6 Peptide, MCG40308 Peptide, Mis5 Peptide, P105MCM Peptide, Mcmd6 Peptide, mis5 Peptide, mmcm6 Peptide, ASP-l1 Peptide, D1Wsu22e Peptide, Minichromosome maintenance 6 Peptide, DNA replication licensing factor MCM6 Peptide, minichromosome maintenance complex component 6 Peptide, minichromosome maintenance complex component 6 L homeolog Peptide, DNA replication licensing factor mcm-6 Peptide, Mcm6 Peptide, TP02_0113 Peptide, PVX_114735 Peptide, CMU_027970 Peptide, MCM6 Peptide, mcm6.L Peptide, mcm-6 Peptide
- Background
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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
Alias Symbols: Mis5, P105MCM, MCG40308
Protein Size: 821 - Gene ID
- 4175
- NCBI Accession
- NM_005915, NP_005906
- UniProt
- Q14566
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