Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (Middle Region) Peptide
MDM2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MDM2 products
- MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KSDSISLSFD ESLALCVIRE ICCERSSSSE STGTPSNPDL DAGVSEHSGD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- MDM2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
- Synonyms
- ACTFS Peptide, HDMX Peptide, hdm2 Peptide, zgc:109834 Peptide, 1700007J15Rik Peptide, AA415488 Peptide, Mdm-2 Peptide, MDM2 proto-oncogene Peptide, MDM2 proto-oncogene S homeolog Peptide, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) Peptide, MDM2 oncogene, E3 ubiquitin protein ligase Peptide, transformed mouse 3T3 cell double minute 2 Peptide, MDM2 Peptide, mdm2.S Peptide, Mdm2 Peptide, mdm2 Peptide
- Background
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This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Alias Symbols: HDMX, hdm2, ACTFS
Protein Size: 430 - Gene ID
- 4193
- NCBI Accession
- NM_001145339, NP_001138811
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