Insulin-Degrading Enzyme (IDE) Peptide
IDE
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all IDE products
- IDE (Insulin-Degrading Enzyme (IDE))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of IDE antibody,
Alternative Names: IDE control peptide, IDE antibody Blocking Peptide, Anti-IDE Blocking Peptide, insulin-degrading enzyme Blocking Peptide, FLJ35968 Blocking Peptide, INSULYSIN Blocking Peptide - Purification
- Immunoaffinity chromatography
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- IDE (Insulin-Degrading Enzyme (IDE))
- Synonyms
- zgc:162603 Peptide, IDE Peptide, 1300012G03Rik Peptide, 4833415K22Rik Peptide, AA675336 Peptide, AI507533 Peptide, INSDEGM Peptide, INSULYSIN Peptide, insulin degrading enzyme Peptide, insulin-degrading enzyme Peptide, metallopeptidase Peptide, IDE Peptide, ide Peptide, LOC591315 Peptide, CC1G_01115 Peptide, Bm1_26615 Peptide, PTRG_10875 Peptide, SJAG_01430 Peptide, EBI_21700 Peptide, VDBG_06702 Peptide, LOAG_08082 Peptide, PGTG_04982 Peptide, Tsp_00424 Peptide, Ide Peptide
- Background
- This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
- Molecular Weight
- 118 kDa
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