anthrax Toxin Receptor 1 (ANTXR1) (Middle Region) Peptide
ANTXR1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ANTXR1 products
- ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ANTXR1 antibody (Catalog #: ARP50040_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))
- Synonyms
- ANTXR1 Peptide, ATR Peptide, TEM8 Peptide, 2310008J16Rik Peptide, 2810405N18Rik Peptide, Antrx1 Peptide, Tem8 Peptide, anthrax toxin receptor 1 Peptide, ANTXR1 Peptide, Antxr1 Peptide
- Background
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ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. ANTXR1 has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.
Alias Symbols: ATR, FLJ10601, FLJ11298, FLJ21776, TEM8
Protein Interaction Partner: BCL2L1,HDAC2,LRP6
Protein Size: 564 - Molecular Weight
- 60 kDa
- Gene ID
- 84168
- NCBI Accession
- NM_032208, NP_115584
- UniProt
- Q9H6X2
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