CD22 Molecule (CD22) (C-Term) Peptide
CD22
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CD22 products
- CD22 (CD22 Molecule (CD22))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- YSALHKRQVG DYENVIPDFP EDEGIHYSEL IQFGVGERPQ AQENVDYVIL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CD22 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CD22 (CD22 Molecule (CD22))
- Synonyms
- A530093D23 Peptide, Lyb-8 Peptide, Lyb8 Peptide, SIGLEC-2 Peptide, SIGLEC2 Peptide, siglec-2 Peptide, CD22 antigen Peptide, CD22 molecule Peptide, Cd22 Peptide, CD22 Peptide
- Background
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CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Alias Symbols: FLJ22814, MGC130020, SIGLEC-2, SIGLEC2
Protein Interaction Partner: AP2M1,ATP2B4,CD19,GRB2,HP,IGHM,INPP5D,LCP2,LYN,PIK3R1,PLCG1,PTPN6,PTPRC,SHC1,ST6GAL1,SYK,AP2A1,AP2M1,CD19,GRB2,INPP5D,LYN,PLCG1,PTPN6,PTPRC,SHC1,SYK
Protein Size: 847 - Molecular Weight
- 95 kDa
- Gene ID
- 933
- NCBI Accession
- NM_001771, NP_001762
- UniProt
- P20273
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