CASP8 and FADD-Like Apoptosis Regulator (CFLAR) (Middle Region) Peptide
CFLAR
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FLIP (CFLAR) products
- FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CFLAR antibody (Catalog #: AVARP02011_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
- Synonyms
- Clarp1 Peptide, cflar Peptide, CFLAR Peptide, FLIP Peptide, CASH Peptide, CASP8AP1 Peptide, CLARP Peptide, Casper Peptide, FLAME Peptide, FLAME-1 Peptide, FLAME1 Peptide, I-FLICE Peptide, MRIT Peptide, c-FLIP Peptide, c-FLIPL Peptide, c-FLIPR Peptide, c-FLIPS Peptide, 2310024N18Rik Peptide, A430105C05Rik Peptide, Cash Peptide, ENSMUSG00000072980 Peptide, Flip Peptide, Gm9845 Peptide, c-Flip Peptide, CASP8 and FADD-like apoptosis regulator a Peptide, CASP8 and FADD like apoptosis regulator Peptide, CASP8 and FADD like apoptosis regulator S homeolog Peptide, CASP8 and FADD-like apoptosis regulator Peptide, cflara Peptide, CFLAR Peptide, cflar Peptide, cflar.S Peptide, Cflar Peptide
- Background
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CFLAR belongs to the peptidase C14A family. It is a apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. The protein acts as an inhibitor of TNFRSF6 mediated apoptosis. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. CFLAR lacks enzymatic (caspase) activity.
Alias Symbols: CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLIP, I-FLICE, MRIT, USURPIN, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, FLAME1
Protein Interaction Partner: CASP3,CASP8,FADD,BCL2L1,CASP3,CASP8,DAXX,FADD,BCL2L1,CASP10,CASP2,CASP3,CASP6,CASP7,CASP8,DAXX,DEDD,DEDD2,FADD,IKBKB,MAP2K4,MAP2K7,NFKB1,PSEN2,RAF1,RIPK1,RIPK2,TNFRSF10B,TRAF1,TRAF2,BCL2L1,CASP10,CASP3,CASP8,CFLAR,DEDD,DEDD2,DOK2,FADD,FAS,ITCH,MAP3K14,NOD1,NOL3,RAF1,RIPK1,RIPK2,SF3B3,TNFRSF10A,TNFRSF10B,TP53,TRAF1,TRAF2,TRAF3,UBC
Protein Size: 480 - Molecular Weight
- 55 kDa
- Gene ID
- 8837
- NCBI Accession
- NM_003879, NP_003870
- UniProt
- O15519
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