Dual Specificity Phosphatase 4 (DUSP4) (C-Term) Peptide
DUSP4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all DUSP4 products
- DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GQLLQFESQV LATSCAAEAA SPSGPLRERG KTPATPTSQF VFSFPVSVGV
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-DUSP4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))
- Synonyms
- zgc:55423 Peptide, DUSP4 Peptide, typ Peptide, hvh2 Peptide, mkp2 Peptide, mkp-2 Peptide, MGC131045 Peptide, HVH2 Peptide, MKP-2 Peptide, MKP2 Peptide, TYP Peptide, 2700078F24Rik Peptide, AI844617 Peptide, BB104621 Peptide, E130306H24Rik Peptide, Mkp-2 Peptide, Mkp2 Peptide, dual specificity phosphatase 4 Peptide, dual specificity phosphatase 4 S homeolog Peptide, dusp4 Peptide, DUSP4 Peptide, dusp4.S Peptide, Dusp4 Peptide
- Background
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The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
Alias Symbols: HVH2, MKP-2, MKP2, TYP
Protein Interaction Partner: GRIN1,GRIN2D,MAPK1,MAPK14,MAPK3,MAPK8,MAPK9,CRMP1,MAPK14,MAPK3,MAPK8,Mapk14
Protein Size: 394 - Molecular Weight
- 43 kDa
- Gene ID
- 1846
- NCBI Accession
- NM_001394, NP_001385
- UniProt
- Q13115
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