Fucose-1-Phosphate Guanylyltransferase (FPGT) (C-Term) Peptide
FPGT
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FPGT products
- FPGT (Fucose-1-Phosphate Guanylyltransferase (FPGT))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SLKMNRCLKY ATMAFGVQDN LKKSVKTLSD IKLLQFFGVC FLSCLDVWNL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-FPGT Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FPGT (Fucose-1-Phosphate Guanylyltransferase (FPGT))
- Synonyms
- DDBDRAFT_0186414 Peptide, DDBDRAFT_0233144 Peptide, DDB_0186414 Peptide, DDB_0233144 Peptide, FPGT Peptide, DKFZp459M111 Peptide, fpgt Peptide, zgc:110694 Peptide, GFPP Peptide, 1700016E03Rik Peptide, fucose-1-phosphate guanylyltransferase Peptide, fucose-1-phosphate guanylyltransferase L homeolog Peptide, fpgt Peptide, FPGT Peptide, fpgt.L Peptide, Fpgt Peptide
- Background
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L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose, the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene.
Alias Symbols: GFPP
Protein Size: 340 - Molecular Weight
- 37 kDa
- Gene ID
- 8790
- NCBI Accession
- NM_001199328, NP_001186257
- UniProt
- E9PNQ2
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