Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) (Middle Region) Peptide
NFKBIA
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NFKBIA products
- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NFKBIA antibody (Catalog #: AVARP09044_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
- Synonyms
- IKBA Peptide, MAD-3 Peptide, NFKBI Peptide, AI462015 Peptide, Nfkbi Peptide, RL/IF-1 Peptide, ECI-6/IKBA Peptide, NFKBIA Peptide, ikbaB Peptide, wu:fb81f08 Peptide, zgc:56666 Peptide, zgc:77616 Peptide, ikbaA Peptide, wu:fj16a07 Peptide, zgc:85769 Peptide, NFKB inhibitor alpha Peptide, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Peptide, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b Peptide, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a Peptide, NFKBIA Peptide, Nfkbia Peptide, nfkbiab Peptide, nfkbiaa Peptide
- Background
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NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine). NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IKBA, MAD-3, NFKBI
Protein Interaction Partner: ARRB1,ARRB2,BTRC,CHUK,CHUK,COMMD1,DYNLL1,ERC1,HDAC1,HDAC3,IKBKB,IKBKB,IKBKB,LCK,NFKB1,RELA,RELA,ARRB1,ARRB2,BTRC,CAPN1,CAPN2,CDC34,CHUK,COMMD1,COPS8,CSNK2A1,CUL1,DYNLL1,EIF2AK2,FBXW11,G3BP2,HDAC1,HDAC3,HNRNPA1,HOXA9,HOXB7,HSPB1,IKBKAP,IKBKB,IKBKE,IKBKG,JAK2,LCK,MAP3K2,MAP3K3,MCM5,MCM7,MED19,NCOR2,NFKB1,NFKB2,NFKBIB,NKIRAS1,NKIRAS2,PIK3R1,POM121,PRKCI,PTPN1,PTPN13,REL,RELA,RPS6KA1,SKP1,SLC25A4,SLC25A5,SRC,SUMO1,SUMO4,TBK1,TNFSF11,TP53,TUBA1B,UBE2D2,UBE2D3,UBE2E3,VCP,AURKA,BARD1,BTRC,CAPN1,CHUK,COMMD1,DYNLL1,FBXW11,G3BP2,HNRNPA1,HOXB7,IKBKAP,IKBKB,LYL1,MAP3K14,MED19,NCOR2,NFKB1,PIK3R1,PIR,POM121,PTPN13,REL,RELA,RPS6KA1,SUMO4,TP53,UBC,UBE2D1,UBE2E3,VCP
Protein Size: 317 - Molecular Weight
- 35 kDa
- Gene ID
- 4792
- NCBI Accession
- NM_020529, NP_065390
- UniProt
- P25963
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