phosphofurin Acidic Cluster Sorting Protein 1 (PACS1) (C-Term) Peptide
PACS1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PACS1 products
- PACS1 (phosphofurin Acidic Cluster Sorting Protein 1 (PACS1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- FLSKKPREKE VDSKSQVIEG ISRLICSAKQ QQTMLRVSID GVEWSDIKFF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PACS1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PACS1 (phosphofurin Acidic Cluster Sorting Protein 1 (PACS1))
- Synonyms
- MRD17 Peptide, AI325977 Peptide, Pacs-1 Peptide, phosphofurin acidic cluster sorting protein 1 Peptide, PACS1 Peptide, Pacs1 Peptide
- Background
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This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.
Alias Symbols: -
Protein Interaction Partner: CLCN7,PKD2,TRPV4,nef,CLCN7,CSNK2A1,FURIN,GGA3,IGF2R,JUN,PKD2,PPP2CA,PPP2CB,VAMP4,CSNK2A1,FGFR1OP,FURIN,GGA3,VAMP4
Protein Size: 366 - Molecular Weight
- 42 kDa
- Gene ID
- 55690
- NCBI Accession
- NM_018026
- UniProt
- Q6VY07
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