Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (N-Term) Peptide
SREBF1
Reactivity: Human
Host: Synthetic
BP, WB
-
- Target See all SREBF1 products
- SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
- Protein Region
- N-Term
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SREBF1 antibody (Catalog #: ARP38419_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
- Synonyms
- SREBP-1c Peptide, SREBP1 Peptide, bHLHd1 Peptide, ADD-1 Peptide, ADD1 Peptide, D630008H06 Peptide, SREBP-1 Peptide, SREBP-1a Peptide, SREBP1c Peptide, Srebp1 Peptide, SCREBP1 Peptide, SREBP-1C Peptide, SREBF1 Peptide, srebp1 Peptide, sterol regulatory element binding transcription factor 1 Peptide, sterol regulatory element binding transcription factor 1 L homeolog Peptide, sterol regulatory element binding protein-1 Peptide, Sterol regulatory element Binding Protein Peptide, SREBF1 Peptide, Srebf1 Peptide, srebf1.L Peptide, SREBP-1 Peptide, srebf1 Peptide, sbp-1 Peptide
- Background
-
SREBF1is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: SREBP1, bHLHd1, SREBP-1c
Protein Interaction Partner: ATXN1,CREBBP,ESR1,ESR2,ID3,LMNA,MAPK1,MAPK3,NR0B1,SMARCD3,SP1,SREBF1,SUMO1,TWIST2,UBE2I,YY1,CREBBP,GAL11,LMNA,MAPK1,MAPK3,NR0B1,SP1,TWIST2,UBE2I,YY1
Protein Size: 1177 - Molecular Weight
- 125 kDa
- Gene ID
- 6720
- NCBI Accession
- NM_001005291, NP_001005291
-
You are here:
