PIAS3 Products
(Protein Inhibitor of Activated STAT, 3 (PIAS3))
Categories
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
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Featured PIAS3 Categories
PIAS3 Antibodies
High quality antibodies with extensive validation data.
PIAS3 ELISA Kits
Reliable ELISA kits for a wide range of species.
PIAS3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PIAS3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (4)
Cat. No.
ABIN6264198
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (8)
- (2)
Cat. No.
ABIN1882116
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (7)
- (2)
Cat. No.
ABIN1882115
Quantity
400 μL
Datasheet
Datasheet
Recommended PIAS3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958916
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381422
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6206678
Quantity
96 tests
Datasheet
Datasheet
Recommended PIAS3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314994
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314993
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3094547
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PIAS3 products
: "Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells." in: PLoS ONE, Vol. 9, Issue 3, pp. e92746, (2014) (PubMed).: "SUMOylation of the GTPase Rac1 is required for optimal cell migration." in: Nature cell biology, Vol. 12, Issue 11, pp. 1078-85, (2010) (PubMed).
: "The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2." in: Journal of cellular biochemistry, Vol. 107, Issue 2, pp. 293-302, (2009) (PubMed).
: "Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 15, pp. 4694-704, (2008) (PubMed).
: "PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element." in: The Journal of biological chemistry, Vol. 282, Issue 31, pp. 22335-43, (2007) (PubMed).
: "Arsenic trioxide affects signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 22, pp. 6817-25, (2006) (PubMed).
: "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3." in: Biochemical and biophysical research communications, Vol. 314, Issue 1, pp. 97-103, (2004) (PubMed).
: "Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 1, pp. 99-104, (2004) (PubMed).
: "Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells." in: Leukemia research, Vol. 28, Issue 1, pp. 71-82, (2003) (PubMed).
: "Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor." in: Biochemical and biophysical research communications, Vol. 306, Issue 2, pp. 610-5, (2003) (PubMed).
Synonyms and alternative names related to PIAS3
protein inhibitor of activated STAT 3 (PIAS3), protein inhibitor of activated STAT 3 (pias3), protein inhibitor of activated STAT 3 (Pias3), protein inhibitor of activated STAT, 3 (Pias3), protein inhibitor of activated STAT 3 L homeolog (pias3.L), PIAS3, Pias3l, ZMIZ5Protein level used designations for PIAS3
- protein inhibitor of activated STAT, 3
- E3 SUMO-protein ligase PIAS3-like
- e3 SUMO-protein ligase PIAS3-like
- E3 SUMO-protein ligase PIAS3
- protein inhibitor of activated STAT protein 3
- zinc finger, MIZ-type containing 5
- KChAP
- potassium channel regulatory protein KChAP
- potassium channel-associated protein
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