anti-Mouse (Murine) PDPK1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Recommended PDPK1 Antibody (supplied by: Log in to see )
- Antigen
-
3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antibodies
show synonyms for this antigen- pdpk1
- MGC82080
- PDK1
- PDPK2
- PRO0461
- Pdk1
- si:zfos-979f1.3
- 1210
- BG02759
- CG1201
- CG1210
- DSTPK61
- Dmel\\CG1210
- Dstpk61
- PDK
- PDK-1
- PDK1/Pk61C
- PK61C
- Pk61C
- Pk61C/PDK1
- dPDK-1
- dPDK1
- dSTPK61
- pk61c
- 3'-phosphoinositide-dependent protein kinase 1
- 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
- ATPDK1
- AtPDK1
- T32M21.110
- T32M21_110
- 3-phosphoinositide dependent protein kinase 1
- 3-phosphoinositide dependent protein kinase 1 L homeolog
- 3-phosphoinositide dependent protein kinase-1
- 3-phosphoinositide-dependent protein kinase 1
- pyruvate dehydrogenase kinase, isozyme 1
- pyruvate dehydrogenase kinase 1
- Phosphoinositide-dependent kinase 1
- 3'-phosphoinositide-dependent protein kinase 1
- PDPK1
- pdpk1.L
- pdpk1
- Pdpk1
- LOC100380750
- pdk1
- PDK1
- Pdk1
- pdk-1
- Epitope
-
pSer241
Alternatives - Reactivity
-
Human, Mouse (Murine), Rat (Rattus)
Alternatives - Host
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Rabbit
Alternatives - Clonality
- Conjugate
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This PDPK1 antibody is un-conjugated
Alternatives - Application
-
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternatives - Options
- Supplier
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- Supplier Product No.
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| Relevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
|---|---|---|---|---|---|---|---|---|---|---|
| 12.45388 | ABIN4344570 | ICC IF IHC IHC (p) WB | Rabbit | pSer241 | Log in to see | Polyclonal | 0 | |||
| 1 | ABIN3043600 | IHC (p) WB | Rabbit | IgG | AA 524-556, C-Term | Log in to see | Polyclonal | 0 | ||
| 1 | ABIN197100 | IF IHC (p) WB | Rabbit | Ser241 | Log in to see | Polyclonal | 5 | |||
| 1 | ABIN196616 | IF IHC (p) WB | Rabbit | pSer241 | Log in to see | Polyclonal | 4 | |||
| 1 | ABIN682948 | IF (p) IHC (p) WB | Rabbit | IgG | pTyr373, pTyr376 | Log in to see | Polyclonal | 0 | ||
| 1 | ABIN711116 | IF (p) IHC (p) WB | Rabbit | IgG | pTyr9 | Log in to see | Polyclonal | 0 | ||
| 1 | ABIN2889054 | IHC (p) ELISA WB | Rabbit | IgG | AA 210-259 | Log in to see | Polyclonal | 0 | ||
| 1 | ABIN2888512 | IHC (p) ELISA WB | Rabbit | IgG | pSer241 | Log in to see | Polyclonal | 0 | ||
| 1 | ABIN1737955 | IHC (p) WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
| 1 | ABIN127128 | IHC (p) IP WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
| 1 | ABIN744677 | IHC (p) WB | HRP | Rabbit | IgG | pSer241 | Log in to see | Polyclonal | 0 | |
| 1 | ABIN334098 | IHC (p) WB | Rabbit | IgG | AA 421-436 | Log in to see | Polyclonal | 0 | ||
| 1 | ABIN462376 | IHC (p) WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
| 1 | ABIN744670 | IHC (p) WB | Biotin | Rabbit | IgG | pSer241 | Log in to see | Polyclonal | 0 | |
| 1 | ABIN1822818 | IHC (p) WB | Rabbit | IgG | pSer241 | Log in to see | Polyclonal | 0 | ||
| 1 | ABIN1822819 | IHC (p) WB | Rabbit | IgG | pSer241 | Log in to see | Polyclonal | 0 | ||
| 1 | ABIN682957 | IHC (p) WB | HRP | Rabbit | IgG | pTyr373, pTyr376 | Log in to see | Polyclonal | 0 | |
| 1 | ABIN711125 | IHC (p) WB | HRP | Rabbit | IgG | pTyr9 | Log in to see | Polyclonal | 0 | |
| 1 | ABIN711140 | IHC (p) WB | HRP | Rabbit | IgG | pSer396 | Log in to see | Polyclonal | 0 | |
| 1 | ABIN711155 | IHC (p) WB | HRP | Rabbit | IgG | pSer410 | Log in to see | Polyclonal | 0 |
General |
|
|---|---|
| Antigen | 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Antibodies |
| Epitope | pSer241 Alternatives |
| Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
| Host | Rabbit Alternatives |
| Clonality | |
| Conjugate | This PDPK1 antibody is un-conjugated Alternatives |
| Application |
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternatives
|
|
1 reference available |
| Supplier | Log in to see |
Product Details anti-PDPK1 AntibodyTarget Details PDPK1 Application Details Handling References for anti-PDPK1 antibody (ABIN744668) Images |
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| Specificity | This phosphorylation site is homologous to Ser244 in Mouse and Rat. |
| Purification | Purified by Protein A. |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human PDK1 around the phosphorylation site of Ser241 |
| Isotype | IgG |
Target Details PDPK1Product Details anti-PDPK1 Antibody Application Details Handling References for anti-PDPK1 antibody (ABIN744668) Images back to top |
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| Antigen | |
| Alternative Name | Pdk1 (PDPK1 Antibody Abstract) |
| Background |
Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Subcellular location: Cytoplasm, Membrane bound Synonyms: PDK1, PDPK2, PDPK2P, PRO0461, 3-phosphoinositide-dependent protein kinase 1, hPDK1, PDPK1 |
| Gene ID | 5170 |
| UniProt | O15530 |
| Pathways | PI3K-Akt Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals |
Application DetailsProduct Details anti-PDPK1 Antibody Target Details PDPK1 Handling References for anti-PDPK1 antibody (ABIN744668) Images back to top |
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| Application Notes |
WB 1:100-1000 IHC-P 1:100-500 IF(IHC-P) 1:50-200 |
| Restrictions | For Research Use only |
HandlingProduct Details anti-PDPK1 Antibody Target Details PDPK1 Application Details References for anti-PDPK1 antibody (ABIN744668) Images back to top |
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| Format | Liquid |
| Concentration | 1 μg/μL |
| Buffer | Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide. |
| Preservative | Sodium azide |
| Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
| Storage | -20 °C |
| Storage Comment | Store at -20°C |
| Expiry Date | 12 months |
References for anti-PDPK1 antibody (ABIN744668)Product Details anti-PDPK1 Antibody Target Details PDPK1 Application Details Handling Images back to top |
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| Product cited in: |
Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: "Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy." in: Epilepsy research, Vol. 112, pp. 137-49, 2015 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human). Further details: Sample: Brain |
ImagesProduct Details anti-PDPK1 Antibody Target Details PDPK1 Application Details Handling References for anti-PDPK1 antibody (ABIN744668) back to top |
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| Supplier Images |
Mouse bone lysates probed with Rabbit Anti-PDK1(ser241) Polyclonal Antibody, Unconjug...
paraformaldehyde-fixed, paraffin embedded human live carcinoma tissue, Antigen retrie...
paraformaldehyde-fixed, paraffin embedded human breast carcinoma tissue, Antigen retr...
Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boil...
Paraformaldehyde-fixed, paraffin embedded rat kidney tissue, Antigen retrieval by boi...
Lane 1: Mouse brain lysates, Lane 2: Mouse heart lysates probed with PDK1(Ser241) Pol...
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