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anti-Mouse (Murine) beta Arrestin 1 Antibodies:
anti-Human beta Arrestin 1 Antibodies:
anti-Rat (Rattus) beta Arrestin 1 Antibodies:
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Human Monoclonal beta Arrestin 1 Primary Antibody for IF, IP - ABIN968033
Attramadal, Arriza, Aoki, Dawson, Codina, Kwatra, Snyder, Caron, Lefkowitz: Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. in The Journal of biological chemistry 1992
Show all 5 Pubmed References
Human Monoclonal beta Arrestin 1 Primary Antibody for IF, IP - ABIN968032
Dalle, Imamura, Rose, Worrall, Ugi, Hupfeld, Olefsky: Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. in Molecular and cellular biology 2002
Show all 5 Pubmed References
Cow (Bovine) Monoclonal beta Arrestin 1 Primary Antibody for IP, WB - ABIN2477633
Hüttenrauch, Pollok-Kopp, Oppermann: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. in The Journal of biological chemistry 2005
beta-arrestin-1 promotes PPARalpha (show PPARA Antibodies)- but represses PPARgamma (show PPARG Antibodies)-mediated transcriptional activities, providing potential regulatory pathway for brown adipose tissue function.
Our data reveal beta-arrestin 1, beta-arrestin 2 (show ARRB2 Antibodies), and AT1R (show AGTRAP Antibodies) as key regulatory molecules in the Frank-Starling mechanism, which involves length-dependent enhancement of cardiac myofilament Ca(2 (show CA2 Antibodies)+) sensitivity.
Arrb1 reduced the chemotherapy-induced Lgr5 (show LGR5 Antibodies) stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling.
findings suggest that knockdown of beta-arrestin 1 can suppress glioblastoma multiforme cell proliferation, invasion and glycolysis by inhibiting Src (show SRC Antibodies) signaling
Results revealed that beta-arrestin-1 regulates lactate metabolism to contribute to beta2-adrenergic receptor (show ADRB2 Antibodies) functions in improved memory formation.
Study reports an X-ray free electron laser crystal structure of the rhodopsin (show RHO Antibodies)-arrestin (show SAG Antibodies) complex, in which the phosphorylated C terminus of rhodopsin (show RHO Antibodies) forms an extended intermolecular beta sheet with the N-terminal beta strands of arrestin (show SAG Antibodies). Phosphorylation was detected at rhodopsin (show RHO Antibodies) C-terminal tail residues T336 and S338.
Beta-arrestin-1 with beta-arrestin-2 shared common mechanisms to suppress podocyte autophagy by negative regulation of ATG12-ATG5 conjugation.
data suggest that beta-arr1 mediated nuclear signaling regulates the production of excretive factors derived from niche astrocytes and expansion of neural precursors in DG, thus maintaining homeostasis of adult hippocampal neurogenesis
beta-arr1 (show SAG Antibodies) has a critical role in modulating ERK (show EPHB2 Antibodies), JNK (show MAPK8 Antibodies) and p38 MAPK (show MAPK14 Antibodies) pathways mediated by TNF-alpha (show TNF Antibodies) in intestinal epithelial cells.
COX-2-derived PGE2 inhibits IL-10 expression in brain microglia through a novel EP2- and beta-arrestin-dependent signaling pathway.
Our results identify a new molecular mechanism involving miR (show MLXIP Antibodies)-326 and Arrb1 as regulators of Sonic hedgehog (show SHH Antibodies) medulloblastoma Cancer stem cells . Specifically, low levels of Arrb1 and miR (show MLXIP Antibodies)-326 trigger and maintain Hh/Gli (show GLI1 Antibodies) signaling and self-renewal
This work demonstrates that the expression of FSHR (show FSHR Antibodies) and LHCGR (show LHCGR Antibodies) can be induced in hGL5 cells but that the FSHR (show FSHR Antibodies)-dependent cAMP/PKA pathway is constitutively silenced, possibly to protect cells from FSHR (show FSHR Antibodies)-cAMP-PKA-induced apoptosis.
This study reveals contrasting abilities of IGF-1R (show IGF1R Antibodies) to interact with each b-arrestin (show SAG Antibodies) isoform, depending on the presence of the ligand and demonstrates the antagonism between the two b-arrestin (show SAG Antibodies) isoforms in controlling IGF-1R (show IGF1R Antibodies) expression and function, which could be developed into a practical anti-IGF-1R (show IGF1R Antibodies) strategy for cancer therapy.
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of D3R through beta-arrestins.
the depleted beta-Arrestin1 reduced the interaction of P300 (show EP300 Antibodies) with Sp1 (show PSG1 Antibodies), thus to reduce Sp1 (show PSG1 Antibodies) binding to hTERT promoter, downregulate hTERT transcription, decrease telomerase activity, shorten telomere length, and promote Reh (show CES1 Antibodies) cell senescence.
Data show that endothelin A receptor (show EDNRA Antibodies) drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 (show ARHGEF11 Antibodies) protein (PDZ-RhoGEF (show ARHGEF11 Antibodies)).
The small GTPase (show RACGAP1 Antibodies) Ras-related protein (show RASD1 Antibodies) 2 (Rap2 (show RAP2A Antibodies)) was found to bind ArrB1 under resting conditions but dissociated upon formyl-Met-Leu-Phe stimulation.
These results were consistent with those seen for beta2-AR. Thus, both beta-arrs negatively control AM1 receptor internalization, which depends on the C-tail of CLR (show DCLK3 Antibodies).
Using in vivo time-lapse imaging and three-dimensional morphology analysis of microglia in intact zebrafish larvae, study found that beta-arrestin1, a multifunctional protein involved in various signal transductions, cell-autonomously regulated the microglial morphology.
Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1 (show YY1 Antibodies), thus relieving PcG-mediated repression of cdx4-hox (show MSH2 Antibodies) pathway.
The identified receptor-phospho-selective mechanism for arrestin (show SAG Antibodies) conformation and the spacing of the multiple phosphate-binding sites in the arrestin (show SAG Antibodies) enable arrestin (show SAG Antibodies) to recognize plethora phosphorylation states of numerous GPCRs.
The presented functional map quantitatively connects critical interactions in the polar core and along the C tail of arrestin (show SAG Antibodies).
Reduced binding of arrestin-1 (show SAG Antibodies) to the phospho-opsin (show RHO Antibodies) form of G90D mutant likely contributes to night blindness caused by this mutation.
3.0 A crystal structure of the bovine arrestin-1 splice variant p44, in which the activation step is mimicked by C-tail truncation
Conformational dynamics of helix 8 in the GPCR (show GPRC6A Antibodies) rhodopsin (show RHO Antibodies) controls arrestin (show SAG Antibodies) activation in the desensitization process
similar to transducin (show GNAT1 Antibodies) activation, rhodopsin (show RHO Antibodies) phosphorylation by GRK1 (show GRK1 Antibodies) and high affinity arrestin-1 (show SAG Antibodies) binding only requires a rhodopsin (show RHO Antibodies) monomer
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
arrestin, beta 1
, arrestin 1
, beta-arrestin 1
, arrestin beta 1
, arrestin beta-1
, arrestin 2