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anti-Mouse (Murine) beta Arrestin 1 Antibodies:
anti-Human beta Arrestin 1 Antibodies:
anti-Rat (Rattus) beta Arrestin 1 Antibodies:
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Cow (Bovine) Monoclonal beta Arrestin 1 Primary Antibody for IP, WB - ABIN2477633
Hüttenrauch, Pollok-Kopp, Oppermann: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. in The Journal of biological chemistry 2005
beta-arrestin-1 promotes PPARalpha (show PPARA Antibodies)- but represses PPARgamma (show PPARG Antibodies)-mediated transcriptional activities, providing potential regulatory pathway for brown adipose tissue function.
Our data reveal beta-arrestin 1, beta-arrestin 2 (show ARRB2 Antibodies), and AT1R (show AGTRAP Antibodies) as key regulatory molecules in the Frank-Starling mechanism, which involves length-dependent enhancement of cardiac myofilament Ca(2 (show CA2 Antibodies)+) sensitivity.
Arrb1 reduced the chemotherapy-induced Lgr5 (show LGR5 Antibodies) stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling.
findings suggest that knockdown of beta-arrestin 1 can suppress glioblastoma multiforme cell proliferation, invasion and glycolysis by inhibiting Src (show SRC Antibodies) signaling
Results revealed that beta-arrestin-1 regulates lactate metabolism to contribute to beta2-adrenergic receptor (show ADRB2 Antibodies) functions in improved memory formation.
Study reports an X-ray free electron laser crystal structure of the rhodopsin (show RHO Antibodies)-arrestin (show SAG Antibodies) complex, in which the phosphorylated C terminus of rhodopsin (show RHO Antibodies) forms an extended intermolecular beta sheet with the N-terminal beta strands of arrestin (show SAG Antibodies). Phosphorylation was detected at rhodopsin (show RHO Antibodies) C-terminal tail residues T336 and S338.
Beta-arrestin-1 with beta-arrestin-2 shared common mechanisms to suppress podocyte autophagy by negative regulation of ATG12-ATG5 conjugation.
data suggest that beta-arr1 mediated nuclear signaling regulates the production of excretive factors derived from niche astrocytes and expansion of neural precursors in DG, thus maintaining homeostasis of adult hippocampal neurogenesis
beta-arr1 (show SAG Antibodies) has a critical role in modulating ERK (show EPHB2 Antibodies), JNK (show MAPK8 Antibodies) and p38 MAPK (show MAPK14 Antibodies) pathways mediated by TNF-alpha (show TNF Antibodies) in intestinal epithelial cells.
COX-2-derived PGE2 inhibits IL-10 expression in brain microglia through a novel EP2- and beta-arrestin-dependent signaling pathway.
Collectively, these results indicate that COX-1 (show COX1 Antibodies)/PGE2/EP4 (show PTGER4 Antibodies) upregulates the beta-arr1 mediated Akt (show AKT1 Antibodies) signaling pathway to provide mucosal protection in colitis.
Beta-arrestin-1 expression is associated with a poor prognosis in serous ovarian cancer patients.Beta-arrestin-1 (show SAG Antibodies) role in the invadopodian function.
Angiotensin II has a role in increasing glomerular permeability by beta-arrestin mediated nephrin (show NPHS1 Antibodies) endocytosis
These results show that b-arrestin1 (show SAG Antibodies) and b-arrestin2 exert differential actions on PAC1R (show ADCYAP1R1 Antibodies) internalization and PAC1R (show ADCYAP1R1 Antibodies)-dependent ERK1/2 activation, and suggest that the two b-arrestin (show SAG Antibodies) isoforms may be involved in fine and precise tuning of the PAC1R (show ADCYAP1R1 Antibodies) signaling pathways.
Conformation of ADRB2 induced by the phosphorylation resulted in beta-arrestin binding.
Bulky Phe substitution of Cys (show DNAJC5 Antibodies)-147 in human arrestin-1 (show SAG Antibodies) likely causes rod degeneration due to reduced stability of the protein, which induces unfolded protein response in expressing cells
Results indicate a mechanism for beta-arrestin1 in the regulation of the prostate cancer procession through inhibiting FOXO3a (show FOXO3 Antibodies).
The results show that PTEN controls multicellular assembly through a membrane-associated regulatory protein complex composed of beta-Arrestin1, ARHGAP21 (show ARHGAP21 Antibodies) and Cdc42 (show CDC42 Antibodies).
These results provide clear evidence that CXCR4- or CCR5-beta-arrestin complexes induce receptor endocytosis and signaling in the absence of G protein coupling and ligand-induced conformational changes of the receptor.
Our results identify a new molecular mechanism involving miR (show MLXIP Antibodies)-326 and Arrb1 as regulators of Sonic hedgehog (show SHH Antibodies) medulloblastoma Cancer stem cells . Specifically, low levels of Arrb1 and miR (show MLXIP Antibodies)-326 trigger and maintain Hh/Gli (show GLI1 Antibodies) signaling and self-renewal
Using in vivo time-lapse imaging and three-dimensional morphology analysis of microglia in intact zebrafish larvae, study found that beta-arrestin1, a multifunctional protein involved in various signal transductions, cell-autonomously regulated the microglial morphology.
Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1 (show YY1 Antibodies), thus relieving PcG-mediated repression of cdx4-hox (show MSH2 Antibodies) pathway.
The identified receptor-phospho-selective mechanism for arrestin (show SAG Antibodies) conformation and the spacing of the multiple phosphate-binding sites in the arrestin (show SAG Antibodies) enable arrestin (show SAG Antibodies) to recognize plethora phosphorylation states of numerous GPCRs.
The presented functional map quantitatively connects critical interactions in the polar core and along the C tail of arrestin (show SAG Antibodies).
Reduced binding of arrestin-1 (show SAG Antibodies) to the phospho-opsin (show RHO Antibodies) form of G90D mutant likely contributes to night blindness caused by this mutation.
3.0 A crystal structure of the bovine arrestin-1 splice variant p44, in which the activation step is mimicked by C-tail truncation
Conformational dynamics of helix 8 in the GPCR (show GPRC6A Antibodies) rhodopsin (show RHO Antibodies) controls arrestin (show SAG Antibodies) activation in the desensitization process
similar to transducin (show GNAT1 Antibodies) activation, rhodopsin (show RHO Antibodies) phosphorylation by GRK1 (show GRK1 Antibodies) and high affinity arrestin-1 (show SAG Antibodies) binding only requires a rhodopsin (show RHO Antibodies) monomer
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
arrestin, beta 1
, arrestin 1
, beta-arrestin 1
, arrestin beta 1
, arrestin beta-1
, arrestin 2