SOD1 Protein (AA 2-154) (His tag)

Catalog No. ABIN1097556

Product Details

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Protein Type: Recombinant

Protein Characteristics: AA 2-154

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SOD1 protein is labelled with His tag.

Purpose: Recombinant Human Superoxide Dismutase [Cu-Zn]/SOD1/Cu-Zn SOD (N-6His)

Sequence: MGSSHHHHHH SSGLVPRGSH MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE FGDNTAGCTS AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI EDSVISLSGD HCIIGRTLVV HEKADDLGKG GNEESTKTGN AGSRLACGVI GIAQ

Characteristics: Recombinant Human Superoxide Dismutase [Cu-Zn]/SOD1 is produced by our E. coli expression system. The target protein is expressed with sequence (Ala2-Gln154) of Human SOD1 fused with a 6His tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Alternative Name: SOD1 (SOD1 Products)

Synonyms: LOC692639 Protein, ALS Protein, ALS1 Protein, IPOA Protein, SOD Protein, hSod1 Protein, homodimer Protein, CG11793 Protein, Cu Protein, Cu-Zn SOD Protein, Cu/Zn SOD Protein, Cu/Zn sod Protein, Cu/Zn superoxide dismutase Protein, Cu/ZnSOD Protein, CuSOD Protein, CuZn SOD Protein, CuZn-SOD Protein, CuZn-SOD1 Protein, CuZnSOD Protein, Cu[2+]/Zn[2+]SOD Protein, Dmel\\CG11793 Protein, G Protein, Mn SOD Protein, SOD-1 Protein, SOD1 Protein, Sod-1 Protein, Sod1 Protein, To Protein, To-1 Protein, Zn SOD Protein, Zn Sod Protein, Zn-SOD Protein, ZnSod Protein, cSOD Protein, cSod Protein, dSOD1 Protein, l(3)108 Protein, l(3)68Af' Protein, l(3)G Protein, sod Protein, sod1 Protein, CU/ZN-SOD Protein, SODC Protein, DKFZP469M1833 Protein, B430204E11Rik Protein, Cu/Zn-SOD Protein, Ipo-1 Protein, Ipo1 Protein, SOD1L1 Protein, XSODB Protein, als Protein, als1 Protein, ipoa Protein, sod1-a Protein, ZSOD Protein, cuzn Protein, Cu/Zn superoxide dismutase Protein, superoxide dismutase 1 Protein, Superoxide dismutase 1 Protein, superoxide dismutase 1, soluble Protein, superoxide dismutase 1 S homeolog Protein, Superoxide dismutase [Cu-Zn] Protein, superoxide dismutase 1 L homeolog Protein, superoxide dismutase [Cu-Zn]-like Protein, superoxide dismutase [Cu-Zn] Protein, superoxide dismutase Sod1 Protein, SOD Protein, SOD1 Protein, Sod1 Protein, sod1 Protein, sod1.S Protein, sod-1 Protein, sod1.L Protein, LOC101451855 Protein, LOC101115136 Protein

Sub Type: Fusionprotein

Background: Superoxide Dismutase [Cu-Zn] (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein that belongs to the Cu-Zn superoxide dismutase family. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. SOD1 neutralizes supercharged oxygen molecules, which can damage cells if their levels are not controlled. The enzyme protects the cell against dangerous levels of superoxide. Zinc binding promotes dimerization and stabilizes the native form. Mutations in SOD1 cause a form of familial amyotrophic lateral sclerosis. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) which is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis.
Alternative Names: Superoxide Dismutase [Cu-Zn], Superoxide Dismutase 1, hSod1, SOD1

Molecular Weight: 18.1 kDa

UniProt: P00441

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis