PCSK9 Protein (AA 35-692) (His tag)

Catalog No. ABIN1691480

Product Details

Target: PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))

Protein Type: Recombinant

Protein Characteristics: AA 35-692

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This PCSK9 protein is labelled with His tag.

Purpose: Recombinant Mouse Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (C-6His)

Sequence: QDEDGDYEEL MLALPSQEDG LADEAAHVAT ATFRRCSKEA WRLPGTYIVV LMEETQRLQI EQTAHRLQTR AARRGYVIKV LHIFYDLFPG FLVKMSSDLL GLALKLPHVE YIEEDSFVFA QSIPWNLERI IPAWHQTEED RSPDGSSQVE VYLLDTSIQG AHREIEGRVT ITDFNSVPEE DGTRFHRQAS KCDSHGTHLA GVVSGRDAGV AKGTSLHSLR VLNCQGKGTV SGTLIGLEFI RKSQLIQPSG PLVVLLPLAG GYSRILNAAC RHLARTGVVL VAAAGNFRDD ACLYSPASAP EVITVGATNA QDQPVTLGTL GTNFGRCVDL FAPGKDIIGA SSDCSTCFMS QSGTSQAAAH VAGIVARMLS REPTLTLAEL RQRLIHFSTK DVINMAWFPE DQQVLTPNLV ATLPPSTHET GGQLLCRTVW SAHSGPTRTA TATARCAPEE ELLSCSSFSR SGRRRGDWIE AIGGQQVCKA LNAFGGEGVY AVARCCLVPR ANCSIHNTPA ARAGLETHVH CHQKDHVLTG CSFHWEVEDL SVRRQPALRS RRQPGQCVGH QAASVYASCC HAPGLECKIK EHGISGPSEQ VTVACEAGWT LTGCNVLPGA SLTLGAYSVD NLCVARVHDT ARADRTSGEA TVAAAICCRS RPSAKASWVQ HHHHHH

Characteristics:

Recombinant Mouse Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (C-6His)

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))

Alternative Name: narc-1-protein (PCSK9 Products)

Synonyms: FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein

Background: Recombinant Mouse Proprotein Convertase Subtilisin/Kexin Type 9/Pcsk9 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Q31-Q692) of Mouse Pcsk9 fused with a polyhistidine tag at the C-terminus.
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development.

Molecular Weight: 74.8 kDa

UniProt: Q80W65