PCSK9 Protein (AA 31-692, C-Term) (His tag)

Catalog No. ABIN1691482

Product Details

Target: PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))

Protein Type: Recombinant

Protein Characteristics: C-Term, AA 31-692

Origin: Macaca nemestrina

Source: Human Cells

Purification tag / Conjugate: This PCSK9 protein is labelled with His tag.

Purpose: Recombinant Macaca nemestrina PCSK9(C-6His)

Sequence: QEDEDGDYEE LVLALRSEED GLADAPEHGA TATFHRCAKD PWRLPGTYVV VLKEETHRSQ SERTARRLQA QAARRGYLTK ILHVFHHLLP GFLVKMSGDL LELALKLPHV DYIEEDSSVF AQSIPWNLER ITPARYRADE YQPPKGGSLV EVYLLDTSIQ SDHREIEGRV MVTDFESVPE EDGTRFHRQA SKCDSHGTHL AGVVSGRDAG VAKGAGLRSL RVLNCQGKGT VSGTLIGLEF IRKSQLVQPV GPLVVLLPLA GGYSRVFNAA CQRLARAGVV LVTAAGNFRD DACLYSPASA PEVITVGATN AQDQPVTLGT LGTNFGRCVD LFAPGEDIIG ASSDCSTCFV SRSGTSQAAA HVAGIAAMML SAEPELTLAE LRQRLIHFSA KDVINEAWFP EDQRVLTPNL VAALPPSTHR AGWQLFCRTV WSAHSGPTRM ATAVARCAQD EELLSCSSFS RSGKRRGERI EAQGGKRVCR AHNAFGGEGV YAIARCCLLP QVNCSVHTAP PAGASMGTRV HCHQQGHVLT GCSSHWEVED LGTHKPPVLR PRGQPNQCVG HREASIHASC CHAPGLECKV KEHGIPAPQE QVIVACEDGW TLTGCSALPG TSHVLGAYAV DNTCVVRSRD VSTTGSTSEE AVAAVAICCR SRHLVQASQE LQHHHHHH

Characteristics: Tag: C-polyHis

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 50 mM HEPES,150 mM NaCl,20 % Glycerol, pH 7.4.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))

Alternative Name: Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (PCSK9 Products)

Synonyms: FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein

Background: Recombinant Rhesus Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Q31-Q692) of Rhesus PCSK9 fused with a polyhistidine tag at the C-terminus.
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.

Molecular Weight: 14&59 kDa

UniProt: A8T662