Interleukin 17a Protein (AA 20-155) (His tag)
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- Target See all Interleukin 17a (IL17A) Proteins
- Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 20-155
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Origin
- Human
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Source
- CHO Cells
- Purification tag / Conjugate
- This Interleukin 17a protein is labelled with His tag.
- Characteristics
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ED50 < 0.3 ng/mL, measured in a bioassay using NHDF cells, corresponding to a specific activity of > 3.3x10^6 units/mg.
AA 20-155 expressed with C-terminal 6xHis. - Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product IL17A Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant humanInterleukin-17A (IL-17A), His remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, human Interleukin-17A (IL-17A), His should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
- Alternative Name
- Interleukin-17A (IL-17A) (IL17A Products)
- Synonyms
- CTLA8 Protein, IL-17 Protein, IL-17A Protein, IL17 Protein, Ctla-8 Protein, Ctla8 Protein, Il17 Protein, ChIL-17 Protein, IL-17F Protein, IL17A Protein, CTLA-8 Protein, interleukin 17A Protein, IL17A Protein, Il17a Protein
- Background
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Interleukin-17A (IL-17A),also known as CTLA-8 and IL-17, is a proinflammatory cytokine belonging to the IL-17 family. It is secreted by Th17 cells, gamma/delta T cells, NK cells and neutrophils. IL-17A signals through IL-17 receptor A in a complex with receptor C or D to regulate NF-kappaB and MAP kinase activities. IL-17A plays important roles in the anti-microbial response and chronic inflammation. It stimulates the production of IL-6, IL-8 and G-CSF in epithelial and endothelial cells, and induces the expression of ICAM-1 in fibroblasts. Clinically, IL-17A has been associated with inflammatory diseases, such as rheumatoid arthritis, psoriasis and multiple sclerosis.Recombinant human Interleukin-17A (rhIL-17A) produced in CHO cells is a glycosylated homodimer chain containing 142 amino acids. A fully biologically active molecule, rhIL-17A has a molecular mass of around 14-22 kDa analyzed by reducing SDS-PAGE.
Synonyms: - Molecular Weight
- 14-22 kDa, observed by reducing SDS-PAGE.
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