TPSB2 Protein (AA 19-275) (His tag)

Catalog No. ABIN2115425

Product Details

Target: TPSB2 (Tryptase beta 2 (TPSB2))

Protein Type: Recombinant

Protein Characteristics: AA 19-275

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This TPSB2 protein is labelled with His tag.

Purpose: Recombinant Human Tryptase β-2/TPSB2 (C-6His)

Sequence: APAPGQALQR VGIVGGQEAP RSKWPWQVSL RVHGPYWMHF CGGSLIHPQW VLTAAHCVGP DVKDLAALRV QLREQHLYYQ DQLLPVSRII VHPQFYTAQI GADIALLELE EPVKVSSHVH TVTLPPASET FPPGMPCWVT GWGDVDNDER LPPPFPLKQV KVPIMENHIC DAKYHLGAYT GDDVRIVRDD MLCAGNTRRD SCQGDSGGPL VCKVNGTWLQ AGVVSWGEGC AQPNRPGIYT RVTYYLDWIH HYVPKKPVDH HHHHH

Characteristics: Recombinant Human Tryptase β-2/TPSB2 produced by transfected human cells is a secreted protein with sequence (Ala19-Pro275) of Human TPSB2 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: TPSB2 (Tryptase beta 2 (TPSB2))

Alternative Name: Tryptase beta-2/TPSB2 (TPSB2 Products)

Synonyms: TPS2 Protein, tryptaseB Protein, tryptaseC Protein, Mcpt6 Protein, tryptase beta 2 (gene/pseudogene) Protein, tryptase beta 2 Protein, TPSB2 Protein, Tpsb2 Protein

Background: Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, β-Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, β-Tryptases are released and participate in provoking inflammatory conditions . β-Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders.
Synonyms: Tryptase Beta-2, Tryptase-2, Tryptase II, TPSB2, TPS2

Molecular Weight: 29.64 kDa

UniProt: P20231