FOLR2 Protein (AA 17-228) (His tag)
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- Target See all FOLR2 Proteins
- FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 17-228
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FOLR2 protein is labelled with His tag.
- Sequence
- AA 17-228
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >90 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product FOLR2 Protein
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Folate Receptor 2 (Fetal) (FOLR2) (AA 17-228) protein (His tag)
FOLR2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Folate Receptor 2 (Fetal) (FOLR2) (AA 9-187) protein (His tag)FOLR2 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Folate Receptor 2 (Fetal) (FOLR2) (AA 21-227) protein (His tag)FOLR2 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Folate Receptor 2 (Fetal) (FOLR2) (AA 1-255) protein (GST tag)FOLR2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Folate Receptor 2 (Fetal) (FOLR2) (AA 36-128) protein (GST tag)FOLR2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Folate Receptor 2 (Fetal) (FOLR2) (AA 17-230) protein (His tag)Crystallography grade FOLR2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Folate Receptor 2 (Fetal) (FOLR2) (AA 21-227) protein (His tag)Crystallography grade FOLR2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris and Glycine, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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- Target
- FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))
- Alternative Name
- FOLR2 (FOLR2 Products)
- Synonyms
- FOLR2 Protein, BETA-HFR Protein, FBP Protein, FBP/PL-1 Protein, FR-BETA Protein, FR-P3 Protein, FBP2 Protein, Folbp-2 Protein, Folbp2 Protein, folate receptor 1 Protein, folate receptor beta Protein, folate receptor 2 (fetal) Protein, FOLR1 Protein, FOLR2 Protein, Folr2 Protein
- Background
- Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68 % and 79 % sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
- Molecular Weight
- 26.5 kDa
- NCBI Accession
- NP_000794
- Pathways
- Dicarboxylic Acid Transport
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