PLAU Protein (AA 21-431) (His tag)
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- Target See all PLAU Proteins
- PLAU (Plasminogen Activator, Urokinase (PLAU))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 21-431
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PLAU protein is labelled with His tag.
- Sequence
- AA 21-431
- Characteristics
- Human PLAU, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 45 kDa. The predicted N-terminus is Ser21, Ile179 & Lys156. The reducing (R) protein migrates as four bands corresponding to the short α chain, long α chain, β chain and unprocessed full-length chain with the molecular mass of 20 kDa, 23 kDa, 32 kDa and 50 kDa respectively in SDS-PAGE due to glycosylation and cleavage.
- Purity
- >92 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product PLAU Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Sodium Acetate, 100 mM NaCl, pH 5.0
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).
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Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).
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- Target
- PLAU (Plasminogen Activator, Urokinase (PLAU))
- Alternative Name
- PLAU (PLAU Products)
- Synonyms
- PLAU Protein, u-PA Protein, ATF Protein, BDPLT5 Protein, QPD Protein, UPA Protein, URK Protein, uPA Protein, UPAM Protein, plasminogen activator, urokinase Protein, urokinase-type plasminogen activator Protein, PLAU Protein, CpipJ_CPIJ002131 Protein, CpipJ_CPIJ006543 Protein, CpipJ_CPIJ013396 Protein, CpipJ_CPIJ013623 Protein, Plau Protein
- Background
- Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys - Pro - Gly - Arg560 - Val561 - Val - Gly - Gly - Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
- Molecular Weight
- 47.2 kDa
- NCBI Accession
- NP_002649
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
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