VEGFD Protein (AA 93-201) (His tag)
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- Target See all VEGFD (Figf) Proteins
- VEGFD (Figf) (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 93-201
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This VEGFD protein is labelled with His tag.
- Sequence
- AA 93-201
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product Figf Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Target
- VEGFD (Figf) (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf))
- Alternative Name
- VEGF-D (Figf Products)
- Synonyms
- FIGF Protein, vegfd Protein, vegf-d Protein, VEGFD Protein, AI325264 Protein, VEGF-D Protein, Vegfd Protein, Vegf-d Protein, vascular endothelial growth factor D Protein, Vascular endothelial growth factor D Protein, VEGFD Protein, vegfd Protein, vegfd.L Protein, Vegfd Protein
- Background
- Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.
- Molecular Weight
- 13.4 kDa
- Pathways
- RTK Signaling
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