TIRAP Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2733787

Product Details

Target: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 3

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This TIRAP protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human TIRAP (transcript variant 3) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Alternative Name: Tirap (TIRAP Products)

Synonyms: mal Protein, wyatt Protein, BACTS1 Protein, Mal Protein, MyD88-2 Protein, AA407980 Protein, C130027E04Rik Protein, Tlr4ap Protein, Wyatt Protein, toll-interleukin 1 receptor (TIR) domain containing adaptor protein Protein, TIR domain containing adaptor protein Protein, toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog Protein, toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Protein, tirap Protein, TIRAP Protein, tirap.L Protein, Tirap Protein

Background: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants however, not all variants have been fully described.

Molecular Weight: 23.7 kDa

NCBI Accession: NP_001034750

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades