ITGAV/ITGB1 Protein (AA 31-992) (His tag)
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- Target See all ITGAV/ITGB1 products
- ITGAV/ITGB1 (Integrin alpha V + beta 1 (ITGAV/ITGB1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 31-992
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ITGAV/ITGB1 protein is labelled with His tag.
- Sequence
- AA 31-992
- Characteristics
- Human ITGAV & ITGB1 Heterodimer Protein, produced by co-expression of ITGAV and ITGB1, has a calculated MW of 113 kDa (ITGAV) and 83.7 kDa (ITGB1). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gln 21 (ITGB1). The reducing (R) protein migrates as 145 kDa (ITGAV) and 116 kDa (ITGB6) respectively due to glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Integrin alpha V + beta 1 (ITGAV/ITGB1) (AA 31-992) (Active) protein
ITGAV/ITGB1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Integrin alpha V + beta 1 (ITGAV/ITGB1) (AA 31-992) (Active) protein (His tag,AVI tag,Biotin)ITGAV/ITGB1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- ITGAV/ITGB1 (Integrin alpha V + beta 1 (ITGAV/ITGB1))
- Alternative Name
- Integrin alpha V beta 1 (ITGAV/ITGB1 Products)
- Background
- Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
- Molecular Weight
- 112.9 kDa (ITGAV) & 83.7 kDa (ITGB1)
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