EPH Receptor A7 Protein (EPHA7) (AA 28-556) (His tag)

Catalog No. ABIN1691230

Product Details

Target: EPH Receptor A7 (EPHA7)

Protein Type: Recombinant

Protein Characteristics: AA 28-556

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This EPH Receptor A7 protein is labelled with His tag.

Purpose: Recombinant Human Ephrin A Receptor 7/EphA7 (C-6His)

Sequence: QAAKEVLLLD SKAQQTELEW ISSPPNGWEE ISGLDENYTP IRTYQVCQVM EPNQNNWLRT NWISKGNAQR IFVELKFTLR DCNSLPGVLG TCKETFNLYY YETDYDTGRN IRENLYVKID TIAADESFTQ GDLGERKMKL NTEVREIGPL SKKGFYLAFQ DVGACIALVS VKVYYKKCWS IIENLAIFPD TVTGSEFSSL VEVRGTCVSS AEEEAENAPR MHCSAEGEWL VPIGKCICKA GYQQKGDTCE PCGRGFYKSS SQDLQCSRCP THSFSDKEGS SRCECEDGYY RAPSDPPYVA CTRPPSAPQN LIFNINQTTV SLEWSPPADN GGRNDVTYRI LCKRCSWEQG ECVPCGSNIG YMPQQTGLED NYVTVMDLLA HANYTFEVEA VNGVSDLSRS QRLFAAVSIT TGQAAPSQVS GVMKERVLQR SVELSWQEPE HPNGVITEYE IKYYEKDQRE RTYSTVKTKS TSASINNLKP GTVYVFQIRA FTAAGYGNYS PRLDVATLEE ATGKMFEATA VSSEQNPVIV DHHHHHH

Characteristics: Recombinant Human Ephrin Type-A Receptor 7/EPHA7 produced by transfected human cells is a secreted protein with sequence (Gln28-Ile556) of Human EPHA7 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: EPH Receptor A7 (EPHA7)

Alternative Name: epha7 (EPHA7 Products)

Synonyms: fc51g03 Protein, wu:fc51g03 Protein, si:dkey-23k6.1 Protein, EHK3 Protein, HEK11 Protein, Cek11 Protein, Ebk Protein, Ehk3 Protein, Hek11 Protein, Mdk1 Protein, CEPHA7 Protein, EPH receptor A7 Protein, eph receptor A7 Protein, ephrin type-B receptor 1-B Protein, Eph receptor A7 Protein, EPHA7 Protein, epha7 Protein, LOC100166161 Protein, Epha7 Protein

Sub Type: Fusionprotein

Background: Ephrin Type-A Receptor 7 (EPHA7) is a single-pass type I membrane protein which belongs to the Eph family of transmembrane receptor tyrosine kinases. It contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EPHA7 is a receptor for members of the ephrin-A family. Eph receptors are largely expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. EPHA7 functions as a repulsive guidance molecule during the targeting of retinal axons to the superior colliculus and of neocortical axons to the thalamus. EPHA7 is expressed at a substantial level in most human lung cancers. The high expression of EPHA7 protein may participate in the malignancy transformation, invasion progression and metastasis of primary hepatocellular carcinoma. EPHA7 may involve in smoking related lung carcinogenesis.
Alternative Names: Ephrin Type-A Receptor 7, EPH Homology Kinase 3, EHK-3, EPH-Like Kinase 11, EK11, hEK11, EPHA7, EHK3, HEK11

Molecular Weight: 60.19 kDa

UniProt: Q15375

Pathways: RTK Signaling