PTPRB Protein (AA 1643-1997) (His-SUMO Tag)
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- Target See all PTPRB Proteins
- PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1643-1997
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PTPRB protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- RQKVSHGRER PSARLSIRRD RPLSVHLNLG QKGNRKTSCP IKINQFEGHF MKLQADSNYL LSKEYEELKD VGRNQSCDIA LLPENRGKNR YNNILPYDAT RVKLSNVDDD PCSDYINASY IPGNNFRREY IVTQGPLPGT KDDFWKMVWE QNVHNIVMVT QCVEKGRVKC DHYWPADQDS LYYGDLILQM LSESVLPEWT IREFKICGEE QLDAHRLIRH FHYTVWPDHG VPETTQSLIQ FVRTVRDYIN RSPGAGPTVV HCSAGVGRTG TFIALDRILQ QLDSKDSVDI YGAVHDLRLH RVHMVQTECQ YVYLHQCVRD VLRARKLRSE QENPLFPIYE NVNPEYHRDP VYSRH
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product PTPRB Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))
- Alternative Name
- PTPRB (PTPRB Products)
- Synonyms
- PTPRB Protein, HPTP-BETA Protein, HPTPB Protein, PTPB Protein, R-PTP-BETA Protein, VEPTP Protein, 3230402H02Rik Protein, C130094E24 Protein, Ptpz Protein, Rptpb Protein, VE-PTP Protein, Veptp Protein, protein tyrosine phosphatase, receptor type B Protein, receptor-type tyrosine-protein phosphatase beta Protein, protein tyrosine phosphatase, receptor type, B Protein, PTPRB Protein, LOC100380677 Protein, Ptprb Protein
- Background
- Plays an important role in blood vessel rodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and rodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel rodeling during bryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin .
- Molecular Weight
- 57.36 kDa
- UniProt
- P23467
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