TRKA Protein (DYKDDDDK-His Tag)

Catalog No. ABIN5505793

Product Details

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This TRKA protein is labelled with DYKDDDDK-His Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human TrkA (C-term DDK/His tag, transcript variant 2) protein expressed in Human HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 1 x PBS, pH 7.4, 10 % glycerol

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Alternative Name: TrkA (NTRK1 Products)

Synonyms: MTC Protein, TRK Protein, TRK1 Protein, TRKA Protein, Trk-A Protein, p140-TrkA Protein, CDHF12 Protein, CDHR16 Protein, HSCR1 Protein, MEN2A Protein, MEN2B Protein, MTC1 Protein, PTC Protein, RET-ELE1 Protein, RET51 Protein, Trk Protein, C80751 Protein, Tkr Protein, TrkA Protein, trk Protein, trka Protein, CTRKA Protein, trkA Protein, neurotrophic receptor tyrosine kinase 1 Protein, ret proto-oncogene Protein, neurotrophic tyrosine kinase, receptor, type 1 Protein, NTRK1 Protein, RET Protein, Ntrk1 Protein, ntrk1 Protein

Background: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Molecular Weight: 46 kDa

NCBI Accession: NP_002520

Pathways: RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process