FUS Protein (AA 136-608) (His-SUMO Tag)

Catalog No. ABIN5710740

Product Details

Target: FUS (Fused in Sarcoma (FUS))

Protein Type: Recombinant

Protein Characteristics: AA 136-608

Origin: Canine Distemper Virus (CDV)

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This FUS protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: QIHWDNLSTI GIIGTDNVHY KIMTRPSHQY LVIKLIPNAS LIENCTKAEL GEYEKLLNSV LEPINQALTL MTKNVKPLQS LGSGRRQRRF AGVVLAGVAL GVATAAQITA GIALHQSNLN AQAIQSLRTS LEQSNKAIEE IREATQETVI AVQGVQDYVN NELVPAMQHM SCELVGQRLG LRLLRYYTEL LSIFGPSLRD PISAEISIQA LIYALGGEIH KILEKLGYSG SDMIAILESR GIKTKITHVD LPGKFIILSI SYPTLSEVKG VIVHRLEAVS YNIGSQEWYT TVPRYIATNG YLISNFDESS CVFVSESAIC SQNSLYPMSP LLQQCIRGDT SSCARTLVSG TMGNKFILSK GNIVANCASI LCKCYSTSTI INQSPDKLLT FIASDTCPLV EIDGATIQVG GRQYPDMVYE GKVALGPAIS LDRLDVGTNL GNALKKLDDA KVLIDSSNQI LETVRRSSFN FGS

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: FUS (Fused in Sarcoma (FUS))

Alternative Name: FUS (FUS Products)

Synonyms: ALS6 Protein, ETM4 Protein, FUS1 Protein, HNRNPP2 Protein, POMP75 Protein, TLS Protein, D430004D17Rik Protein, D930039C12Rik Protein, Fus1 Protein, Tls Protein, FUS/TLS Protein, FUS RNA binding protein Protein, fused in sarcoma Protein, FUS Protein, Fus Protein

Target Type: Viral Protein

Background: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell mbrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell mbranes. Directs fusion of viral and cellular mbranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell mbrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular mbrane, inducing the fusion between cell and virion mbranes. Later in infection, F proteins expressed at the plasma mbrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis .

Molecular Weight: 67.5 kDa

UniProt: P12569