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ARHGDIA Protein (AA 2-204) (GST tag)

ARHGDIA Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Catalog No. ABIN5712033
  • Target See all ARHGDIA Proteins
    ARHGDIA (rho GDP Dissociation Inhibitor (GDI) alpha (ARHGDIA))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 2-204
    Origin
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 5
    • 4
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This ARHGDIA protein is labelled with GST tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    AEQEPTAEQL AQIAAENEED EHSVNYKPPA QKSIQEIQEL DKDDESLRKY KEALLGRVAV SADPNVPNVV VTGLTLVCSS APGPLELDLT GDLESFKKQS FVLKEGVEYR IKISFRVNRE IVSGMKYIQH TYRKGVKIDK TDYMVGSYGP RAEEYEFLTP VEEAPKGMLA RGSYSIKSRF TDDDKTDHLS WEWNLTIKKD WKD
    Purification
    SDS-PAGE
    Purity
    > 90 %
    Top Product
    Discover our top product ARHGDIA Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Storage
    -80 °C,4 °C,-20 °C
    Storage Comment
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    ARHGDIA (rho GDP Dissociation Inhibitor (GDI) alpha (ARHGDIA))
    Alternative Name
    GDIR1 (ARHGDIA Products)
    Synonyms
    GDIA1 Protein, NPHS8 Protein, RHOGDI Protein, RHOGDI-1 Protein, Bles01 Protein, zgc:55554 Protein, zgc:77681 Protein, wu:fa96g11 Protein, ARHGDIA Protein, NV15502 Protein, 5330430M07Rik Protein, Gdi-1 Protein, Rho-GDI Protein, RhoDGI Protein, RhoGDI-1 Protein, arhgdia Protein, MGC84535 Protein, gdia1 Protein, rhogdi Protein, rhogdi-1 Protein, rhogdi1 Protein, Rho GDP dissociation inhibitor alpha Protein, Rho GDP dissociation inhibitor (GDI) alpha Protein, rho GDP-dissociation inhibitor 2 Protein, Rho GDP dissociation inhibitor (GDI) alpha L homeolog Protein, ARHGDIA Protein, Arhgdia Protein, arhgdia Protein, LOC100120432 Protein, arhgdia.L Protein
    Background
    Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from th, and the subsequent binding of GTP to th. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting th from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from mbranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SA5A and PLXNB3 that lead to inactivation of RAC1.
    Molecular Weight
    50.5 kDa
    UniProt
    P52565
    Pathways
    Neurotrophin Signaling Pathway
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