Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

p53 Protein (AA 1-391, full length) (His tag)

TP53 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Catalog No. ABIN5712978
  • Target See all p53 (TP53) Proteins
    p53 (TP53) (Tumor Protein P53 (TP53))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-391, full length
    Origin
    • 18
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Source
    • 25
    • 13
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This p53 protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    MEDSQSDMSI ELPLSQETFS CLWKLLPPDD ILPTTATGSP NSMEDLFLPQ DVAELLEGPE EALQVSAPAA QEPGTEAPAP VAPASATPWP LSSSVPSQKT YQGNYGFHLG FLQSGTAKSV MCTYSISLNK LFCQLAKTCP VQLWVTSTPP PGTRVRAMAI YKKSQHMTEV VRRCPHHERC SDGDGLAPPQ HLIRVEGNPY AEYLDDRQTF RHSVVVPYEP PEVGSDYTTI HYKYMCNSSC MGGMNRRPIL TIITLEDSSG NLLGRDSFEV RVCACPGRDR RTEEENFRKK EEHCPELPPG SAKRALPTST SSSPQQKKKP LDGEYFTLKI RGRERFEMFR ELNEALELKD ARAAEESGDS RAHSSYPKTK KGQSTSRHKK PMIKKVGPDS D
    Purification
    SDS-PAGE
    Purity
    > 90 %
    Top Product
    Discover our top product TP53 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Storage
    -80 °C,4 °C,-20 °C
    Storage Comment
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    p53 (TP53) (Tumor Protein P53 (TP53))
    Alternative Name
    P53 (TP53 Products)
    Synonyms
    BCC7 Protein, LFS1 Protein, P53 Protein, TRP53 Protein, p53 Protein, Trp53 Protein, brp53 Protein, drp53 Protein, etID22686.5 Protein, fb40d06 Protein, wu:fb40d06 Protein, zgc:111919 Protein, Tp53 Protein, bbl Protein, bfy Protein, bhy Protein, p44 Protein, tp53 Protein, Xp53 Protein, TP53 Protein, tumor protein p53 Protein, cellular tumor antigen p53 Protein, transformation related protein 53 Protein, tumor protein p53 L homeolog Protein, TP53 Protein, CpipJ_CPIJ002758 Protein, Tp53 Protein, tp53 Protein, Trp53 Protein, tp53.L Protein
    Background
    Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction ses to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and se to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
    Molecular Weight
    47.5 kDa
    UniProt
    P10361
    Pathways
    p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
You are here:
Support