JTB Protein (AA 31-105) (His tag)
JTB
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 85 % by SDS - PAGE
SDS
1 image
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- Target See all JTB Proteins
- JTB (Jumping Translocation Breakpoint (JTB))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 31-105
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This JTB protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSEAPVQEE KLSASTSNLP CWLVEEFVVA EECSPCSNFR AKTTPECGPT GYVEKITCSS SKRNEFKSCR SALMEQRL
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product JTB Protein
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Jumping Translocation Breakpoint (JTB) (AA 31-105) protein (His tag)
JTB Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Jumping Translocation Breakpoint (JTB) (AA 1-146) protein (GST tag)JTB Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 10 % glycerol, 1 mM DTT
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- JTB (Jumping Translocation Breakpoint (JTB))
- Alternative Name
- JTB (JTB Products)
- Synonyms
- HJTB Protein, HSPC222 Protein, PAR Protein, hJT Protein, Gm622 Protein, JTB Protein, jumping translocation breakpoint Protein, JTB Protein, Jtb Protein
- Background
- Jumping translocation breakpoint, also known as JTB, is required for normal cytokinesis during mitosis. This protein plays a role in the regulation of cell proliferation. This protein may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. It lnhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. Recombinant human JTB protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 10.7 kDa (98aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_006685
- UniProt
- O76095
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