CD24 Protein (AA 27-53) (Fc Tag)

Catalog No. ABIN6253491

Product Details

Target: CD24 (CD24 Molecule (CD24))

Protein Type: Recombinant

Protein Characteristics: AA 27-53

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CD24 protein is labelled with Fc Tag.

Purpose: CD24 (mouse):Fc (human) (rec.)

Specificity: The extracellular domain of mouse CD24 (aa 27-53) is fused at the C-terminus to the Fc portion of human IgG1.

Characteristics: Protein. The extracellular domain of mouse CD24 (aa 27-53) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.06EU/μg purified protein (LAL test, Lonza). Lyophilized. Contains PBS. Purity: >90 % (SDS-PAGE). CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. It is widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently, a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).

Purity: >90 % (SDS-PAGE)

Endotoxin Level: <0.06EU/μg purified protein (LAL test, Lonza).

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Handling Advice: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: CD24 (CD24 Molecule (CD24))

Alternative Name: CD24 (CD24 Products)

Synonyms: CD24A Protein, Cd24a Protein, CD24 molecule Protein, CD24 Protein, Cd24 Protein

Background:

Alternate Names/Synonyms: M1/69-J11D Heat Stable Antigen, Nectadrin, Lymphocyte Antigen 52, X62 Heat Stable Antigen (HSA), Ly-52

Product Description: CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. It is widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently, a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).

UniProt: P25063

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation