SIGIRR Protein (AA 1-118) (Fc Tag)

Catalog No. ABIN6253500

Product Details

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Protein Type: Recombinant

Protein Characteristics: AA 1-118

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SIGIRR protein is labelled with Fc Tag.

Purpose: SIGIRR (human):Fc (human) (rec.)

Specificity: Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.

Characteristics: Protein. Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.06EU/μg purified protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >90 % (SDS-PAGE). SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.

Purity: >90 % (SDS-PAGE)

Endotoxin Level: <0.06EU/μg purified protein (LAL test, Lonza).

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Alternative Name: SIGIRR (SIGIRR Products)

Synonyms: TIR8 Protein, AI256711 Protein, sc:d148 Protein, RGD1306732 Protein, single Ig and TIR domain containing Protein, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Protein, SIGIRR Protein, Sigirr Protein, sigirr Protein

Background:

Alternate Names/Synonyms: Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule

Product Description: SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.

Pathways: Toll-Like Receptors Cascades