TIGAR Protein (AA 1-270) (His tag)
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- Target See all TIGAR Proteins
- TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-270
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This TIGAR protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- TIGAR, 1-270aa, Human, His tag, E.coli
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product TIGAR Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerol
- Storage
- 4 °C
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- Target
- TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
- Alternative Name
- TIGAR (TIGAR Products)
- Synonyms
- AA793651 Protein, AI595337 Protein, C79710 Protein, C85509 Protein, Tigar Protein, Trp53 induced glycolysis repulatory phosphatase Protein, Tigar Protein
- Background
- TIGAR, also known as TP53-induced glycolysis and apoptosis regulator, is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. TIGAR specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. These facts indicate that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses. Recombinant human TIGAR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: TP53-induced glycolysis and apoptosis regulator,. NCBI no.: NP_065108
- Molecular Weight
- 32.6 kDa (294aa), confirmed by MALDI-TOF
- Pathways
- Warburg Effect
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