TIGAR Protein (AA 1-270) (His tag)

Catalog No. ABIN7279263

Product Details

Target: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Protein Type: Recombinant

Protein Characteristics: AA 1-270

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TIGAR protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: TIGAR, 1-270aa, Human, His tag, E.coli

Purity: > 90 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerol

Storage: 4 °C

Target Details

Target: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Alternative Name: TIGAR (TIGAR Products)

Synonyms: AA793651 Protein, AI595337 Protein, C79710 Protein, C85509 Protein, Tigar Protein, Trp53 induced glycolysis repulatory phosphatase Protein, Tigar Protein

Background: TIGAR, also known as TP53-induced glycolysis and apoptosis regulator, is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. TIGAR specifically functions to block glycolysis, leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. These facts indicate that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses. Recombinant human TIGAR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: TP53-induced glycolysis and apoptosis regulator,. NCBI no.: NP_065108

Molecular Weight: 32.6 kDa (294aa), confirmed by MALDI-TOF

Pathways: Warburg Effect