IGSF11 Protein (AA 23-241) (Fc Tag,AVI tag,Biotin)
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- Target See all IGSF11 Proteins
- IGSF11 (Immunoglobulin Superfamily, Member 11 (IGSF11))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 23-241
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IGSF11 protein is labelled with Fc Tag,AVI tag,Biotin.
- Sequence
- AA 23-241
- Specificity
- Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IGSF11 Protein
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- Comment
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Ready-to-use AvitagTM biotinylated protein:
The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.
This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled. - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- IGSF11 (Immunoglobulin Superfamily, Member 11 (IGSF11))
- Alternative Name
- VSIG3 (IGSF11 Products)
- Synonyms
- sc:d812 Protein, seurat Protein, BT-IgSF Protein, CT119 Protein, CXADRL1 Protein, Igsf13 Protein, VSIG3 Protein, 1700025L02Rik Protein, immunoglobulin superfamily member 11 Protein, immunoglobulin superfamily member 11 L homeolog Protein, immunoglobulin superfamily, member 11 Protein, IGSF11 Protein, igsf11 Protein, igsf11.L Protein, Igsf11 Protein
- Background
- VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain. The function of VSIG3 is to stimulate cell growth through homophilic interactions. In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. In addition, VSIG-3 is also a ligand of B7 family member VISTA/PD-1H and inhibits human T-cell functions through a novel VSIG-3/VISTA pathway. VSIG-3/VISTA co-inhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders.
- Molecular Weight
- 51.5 kDa
- NCBI Accession
- NP_001015887
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