NRG1-beta 1 Protein (AA 2-246) (Fc Tag)

Catalog No. ABIN7504486

Product Details

Target: NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))

Protein Type: Recombinant

Protein Characteristics: AA 2-246

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This NRG1-beta 1 protein is labelled with Fc Tag.

Purpose: Human NRG1 Beta 1 Protein

Sequence: Ser2-Lys246

Characteristics: Recombinant Human NRG1 Beta 1 Protein is expressed from HEK293 with hFc tag at the N-terminus.It contains Ser2-Lys246.

Purity: > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))

Alternative Name: NRG1 Beta 1 (NRG1-beta 1 Products)

Background: Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.

Molecular Weight: 54.00 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.